Unconventional Roles of Dynein Light Chains in Axonal Outgrowth and Neurogenesis

Many forms of cell motility, including neurite outgrowth, require coordination of the actin and microtubule cytoskeletons. We found that one light chain subunit of cytoplasmic dynein (i.e., Tctex-1) acts as a regulatory link between the two cytoskeleton systems and plays an important role in the development of hippocampal neurons, including neurite outgrowth.